Sodium glucose transporters are proteins responsible for reabsorption of glucose from kidneys. This protein family has two members: sodium glucose cotransporter-1 (SGLT1) and sodium glucose cotransporter-2 (SGLT2). SGLT2 is expected to reabsorb 90% of the glucose from kidneys, while SGLT1 absorbs the remaining 10%. SGLT2 inhibitors are drugs that affect the action of SGLT2 proteins, thereby reducing blood glucose levels. Hence, these are important in the treatment for type II diabetes. SGLT2 inhibitors called glifozins have four members: canaglifozin, dapaglifozins, ipraglifozin, and empaglifozins. Canaglifozin are most widely used and found to have more affinity toward SGLT2. Besides reducing the blood glucose level, it also lowers blood pressure and promotes weight loss.
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Global SGLT2 Inhibitors Market Witness Most Promising Rise in Demand:
Based on inhibitor molecule, three SGLT2 inhibitors have been approved and recommended in type II diabetes. These are canaglifozin, dapaglifozin, and empaglifozin. These drugs differ on their patient selection and related side effects. For instance, canaglifozin has a concern of hyperkalemia while dapaglifozin has concern in development of bladder cancer and accordingly the patient selection of these treatment types differ. All of the SGLT2 inhibitors are administered orally; however, their kinetics and time of action differ. Canaglifozin is the most widely used among other SGLT2 inhibitors, and very few generic brands are available in the markets for this drug. Dapaglifozin has no generic brands available in the market and is marketed by Boehringer Ingelheim GmbH.
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Key Players of SGLT2 Inhibitors Market Report:
Major players in the SGLT2 inhibitors market are Boehringer Ingelheim GmbH, Janssen Pharmaceutical (part of Johnson & Johnson), GRUPO TECNIMEDE, Unichem Laboratories Ltd., Edifício Bluepharma, and AstraZeneca Pharmaceuticals LP.
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